Wuji Wan Formulae Decomposition IC50of Formula /μg(crude drug) •mL-1 Formula IC50
A: HL B: WZY C: BS
single HLextract 148.67 ± 39.02 - - 148.67 ± 39.02
single WZYextract - 1461.11 ± 170.40 - 1461.11 ± 170.40
single BSextract - - 8.02e+31 ± 1.96e+32 8.02e+31 ± 1.96e+32
1#F extract 127.23 ± 10.76 42.41 ± 3.58*) 127.23 ± 10.76Ⅲ) 296.88 ± 25.12
2#F extract 131.66 ± 2.94 87.77 ± 1.96*) 263.33 ± 5.89Ⅲ) 482.78 ± 10.81
3#F extract 221.22 ± 14.55 2) 442.45 ± 29.09*) 884.91 ± 58.19Ⅲ) 1548.60 ± 101.85
4#F extract 95.51 ± 17.23 1) 15.91 ± 2.87*) 95.51 ± 17.23Ⅲ) 206.94 ± 37.34
5#F extract 177.27 ± 3.98 59.09 ± 1.32*) 354.54 ± 7.97Ⅲ) 590.91 ± 13.29
6#F extract 79.50 ± 14.96 2) 79.50 ± 14.96*) 39.75 ± 7.48Ⅲ) 198.75 ± 37.41
7#F extract 155.20 ± 7.96 12.93 ± 0.66*) 155.20 ± 7.96Ⅲ) 323.35 ± 16.59
8#F extract 101.69 ± 11.64 1) 16.94 ± 1.94*) 25.42 ± 2.91Ⅲ) 144.06 ± 16.50
9#F extract 91.47 ± 43.93 1) 45.73 ± 21.96*) 45.73 ± 21.96Ⅲ) 182.94 ± 87.87
Note: (1) the decomposition IC50 was calculated by table 1 ratios;
(2) compared with the IC50 of HL,1)P<0.05, 2)P<0.01, 3)P<0.001; compared with the IC50 of WZY, *)P<0.001; compared with the IC50 of BS, Ⅲ)P<0.001.
Table 3e: The IC50 values of Wuji Wan on the activities of CYP2E1 ( , n=6) (continue 5).