Wuji Wan Formulae Decomposition IC50of Formula/μg(crude drug) •mL-1 Formula IC50
A: HL B: WZY C: BS
single HLextract 38.96 ± 3.377 - - 38.96 ± 3.377
single WZYextract - 871.96 ± 59.277 - 871.96 ± 59.277
single BSextract - - 15519.17 ± 1438.261 15519.17 ± 1438.261
1#F extract 18.50 ± 1.148 3) 6.17 ± 0.383*) 18.50 ± 1.148Ⅲ) 43.17 ± 2.678
2#F extract 16.49 ± 1.335 3) 11.00 ± 0.890*) 32.99 ± 2.669Ⅲ) 60.47 ± 4.893
3#F extract 39.45 ± 4.460 78.89 ± 8.919*) 157.78 ± 17.838Ⅲ) 276.12 ± 31.217
4#F extract 61.57 ± 3.724 3) 10.26 ± 0.621*) 61.57 ± 3.724Ⅲ) 133.40 ± 8.068
5#F extract 35.42 ± 2.469 11.81 ± 0.823*) 70.85 ± 4.937Ⅲ) 118.08 ± 8.229
6#F extract 35.39 ± 1.374 1) 35.39 ± 1.374*) 17.69 ± 0.687Ⅲ) 88.47 ± 3.434
7#F extract 30.89 ± 2.434 2) 2.57 ± 0.203*) 30.89 ± 2.434Ⅲ) 64.36 ± 5.072
8#F extract 24.80 ± 1.118 3) 4.13 ± 0.186*) 6.20 ± 0.280Ⅲ) 35.13 ± 1.584
9#F extract 19.95 ± 2.345 3) 9.98 ± 1.172*) 9.98 ± 1.172Ⅲ) 39.91 ± 4.690
Note: (1) the decomposition IC50 was calculated by table 1 ratios;
(2) compared with the IC50 of HL,1)P<0.05, 2)P<0.01, 3)P<0.001; compared with the IC50 of WZY, *)P<0.001; compared with the IC50 of BS, Ⅲ)P<0.001.
Table 3f: The IC50 values of Wuji Wan on the activities of CYP3A1/3A2 ( , n=6) (continue 6).