Figure 7: Schematics of Model II vascular tissue composed of endothelial cells (oriented longitudinally) and smooth muscle cells (oriented circumferentially). To generate this tissue mimic, the cell sheet on a tray contains two differently patterned cell sheets composed of two individual cell types in different regions of the tray. ECs are oriented parallel to the long axis of the roller, whereas SMCs in the rear of the tray are oriented in a perpendicular direction. After rolling of the cell sheet, the resulting tubular vessel should exhibit cellular alignments similar to those of a native vessel.