Histological evaluation of the tissue response point value 0 1 2 3 4 average score 0 – 0.49 0.5 – 1.49 1.5 – 2.49 2.5 – 3.49 from 3.5 inflammation none mild moderate severe   fibrosis none narrow band moderate band wide band extensive band macrophages none mild moderate severe   foreign body giant cells none mild moderate severe   fibrin none little fibrin moderate amount large amount

Table 2: The evaluation score used to estimate the tissue response of each sample including the interpretation of the average score.