Dynamic - Femur
8 wks   L2/BS L1/BS L2_only/BS L1_only/BS sLS/BS dLS/BS LS/BS MS/BS(/day) sLS/LS dLS/LS dLS/sLS MAR(mm/day) BFR
Male mean 43.97 23.92 30.64 10.59 41.24 13.32 54.56 33.94 75.99 24.01 32.43 2.31 78.08
  std 6.54 5.83 3.98 3.69 4.09 3.89 7.00 5.28 4.40 4.40 7.93 0.53 21.50
Female mean 55.12 28.38 38.02 11.28 49.29 17.10 66.39 41.75 74.38 25.62 35.57 1.99 82.66
  std 6.51 5.31 5.88 3.47 3.14 4.37 3.83 3.80 5.39 5.39 10.51 0.41 17.32
16 wks p 9.1E-03 1.7E-01 1.6E-02 7.3E-01 3.0E-03 1.1E-01 6.8E-03 1.4E-02 5.5E-01 5.5E-01 5.4E-01 2.6E-01 6.8E-01
Male mean 51.77 35.95 29.90 14.08 43.98 21.87 65.85 43.86 67.05 32.95 49.83 0.62 27.14
  std 6.14 4.78 3.85 2.35 3.24 3.94 5.94 4.77 3.67 3.67 8.28 0.07 3.56
Female mean 53.75 33.38 33.97 13.60 47.57 19.78 67.35 43.57 70.75 29.25 42.14 1.25 54.76
  std 4.00 2.56 2.16 2.04 2.91 2.84 3.76 3.00 3.35 3.35 6.60 0.14 8.05
  p 4.6E-01 2.1E-01 2.4E-02 6.7E-01 3.5E-02 2.4E-01 5.6E-01 8.8E-01 5.4E-02 5.4E-02 6.0E-02 5.2E-07 6.1E-06
Static - Femur Osteogenic - Femur Osteoclastic - Femur
8 wks   BV/TV Tb.Th Tb.N Tb.Sp   AP/BS AP_L2/BS AP_only/BS   TRAP/BS TRAP_L2/BS TRAP_only/BS TRAP_on/TRAP
Male mean 14.04 54.12 2.70 330.60 mean 64.80 12.28 52.88 mean 10.37 2.19 8.17 89.69
  std 3.10 12.90 0.31 37.39 std 4.89 4.71 6.98 std 3.62 1.04 3.33 3.88
Female mean 7.47 34.15 2.23 432.91 mean 71.22 20.22 51.00 mean 14.51 2.22 12.29 82.60
  std 1.13 2.62 0.31 68.74 std 8.51 7.45 4.72 std 5.08 1.39 3.95 6.36
16 wks p 2.6E-03 1.2E-02 1.8E-02 4.3E-03 p 9.1E-2 2.6E-2 5.3E-01 p 8.3E-2 9.6E-01 4.3E-02 2.0E-02
Male mean 16.48 45.83 3.62 235.55 mean 63.18 23.00 39.74 mean 9.77 5.03 4.92 88.52
  std 3.81 7.55 0.38 35.16 std 11.87 6.89 7.68 std 3.55 1.91 2.02 2.71
Female mean 5.51 22.92 2.39 408.57 mean 63.78 24.51 38.81 mean 13.86 6.88 7.79 74.61
  std 0.93 1.89 0.31 59.37 std 8.68 2.32 8.65 std 5.48 2.44 3.67 7.56
  p 5.3E-05 3.6E-05 7.6E-06 1.7E-05 p 9.4E-01 7.0E-01 5.6E-01 p 2.6E-01 2.8E-01 3.0E-01 2.8E-02
Dynamic - Vertebra
8 wks   L2/BS L1/BS L2_only/BS L1_only/BS sLS/BS dLS/BS LS/BS MS/BS(/day) sLS/LS dLS/LS dLS/sLS MAR(mm/day) BFR
Male mean 36.43 13.85 30.63 8.05 38.67 5.80 44.47 25.14 87.44 12.56 14.59 1.19 29.28
  std 6.34 4.61 4.77 2.72 4.78 2.41 6.95 4.62 3.35 3.35 4.49 0.23 4.99
Female mean 47.32 23.78 34.15 10.61 44.76 13.17 57.93 35.55 77.39 22.61 29.52 1.44 51.32
  std 3.49 2.53 3.29 1.58 2.47 2.07 2.67 2.04 3.18 3.18 5.44 0.14 6.03
16 wks p 2.9E-03 7.0E-04 1.3E-01 5.5E-02 1.5E-02 3.9E-05 1.6E-03 5.6E-04 5.7E-05 5.7E-05 6.0E-05 3.0E-02 3.2E-06
Male mean 24.05 13.27 21.01 10.23 31.24 3.05 34.28 18.66 91.98 8.02 8.93 0.92 16.86
  std 5.98 3.91 4.49 2.35 6.30 1.85 7.86 4.76 3.77 3.77 4.59 0.18 5.04
Female mean 35.42 19.43 28.21 12.22 40.43 7.21 47.64 27.42 85.07 14.93 17.66 1.18 32.24
  std 6.11 2.56 4.99 2.57 3.51 1.33 4.78 3.04 1.34 1.34 1.86 0.10 4.21
  p 2.1E-03 2.9E-03 9.0E-03 1.3E-01 4.2E-03 1.9E-04 1.6E-03 9.0E-04 9.4E-04 9.4E-04 6.9E-04 5.7E-03 1.3E-05
Static - Vertebra Osteogenic - Vertebra Osteoclastic - Vertebra
8 wks   BV/TV Tb.Th Tb.N Tb.Sp   AP/BS AP_L2/BS AP_only/BS   TRAP/BS TRAP_L2/BS TRAP_only/BS TRAP_on/TRAP
Male mean 20.51 61.28 3.45 330.60 mean 66.90 22.06 45.18 mean 8.68 3.64 4.90 87.97
  std 2.50 8.24 0.24 37.39 std 9.41 6.96 5.46 std 3.27 1.40 2.61 3.83
Female mean 16.15 47.56 3.46 432.91 mean 78.15 30.05 48.41 mean 13.65 5.13 8.68 82.86
  std 3.27 10.81 0.29 68.74 std 2.10 2.37 2.56 std 3.86 1.60 2.57 82.86
16 wks p 1.0E-02 1.4E-02 9.3E-01 4.3E-03 p 1.9E-02 2.2E-02 8.3E-02 p 1.5E-02 6.7E-02 2.7E-02 8.0E-02
Male mean 14.44 40.72 3.57 235.55 mean 67.10 17.11 49.81 mean 10.30 3.66 6.52 84.58
  std 3.08 7.73 0.31 35.16 std 7.25 4.78 5.49 std 2.41 0.80 2.85 4.19
Female mean 11.83 41.65 2.80 408.57 mean 71.14 24.84 46.94 mean 16.22 5.84 10.34 81.77
  std 3.23 5.23 0.48 59.37 std 7.66 4.59 4.68 std 2.44 1.45 1.73 5.70
  p 1.2E-01 7.8E-01 2.7E-03 1.7E-05 p 3.0E-01 5.3E-03 8.0E-01 p 2.5E-04 3.4E-03 2.1E-05 2.8E-01
Table 4: Histomorphometric measurements of male and female C57Bl/6 mice taken at 8 and 16 weeks of age (units are % except MAR and BFR)