Donor condition (recipient number) EF % ESV μl EDV μl AWTd mm PWTd mm Border zone mm Infarct mm
Young (n = 15) Baseline Day 2 post-MI Day 28 post-MI 50.1±2.2 32.1±3.4* 39.0±5.9*‡ 33.2±3.4 42.1±5.6* 41.2±6.7 66.4±5.1 61.9±7.3 67.6±9.6 0.73±0.04 0.72±0.04 0.69±0.05 0.67±0.05 0.63±0.04 0.59±0.04 0.51±0.06 0.49±0.06
Middle-aged (n = 12) Baseline Day 2 post-MI Day 28 post-MI 50.6±4.0 31.7±4.1* 32.6±3.8 34.4±3.4 42.6±8.9* 56.4±12.3*‡⌂ 69.5±4.0 62.5±12.8 83.5±16.3#◊⌂ 0.73±0.04 0.70±0.03 0.73±0.04 0.70±0.03 0.62±0.04 0.55±0.08 0.52±0.08 0.46±0.09
Old (n = 17) Baseline Day 2 post-MI Day 28 post-MI 50.1±4.6 32.3±4.3* 23.8±5.5*§Ω 33.1±5.9 43.0±9.0 78.3±28.1*‡Ω 65.9±8.6 63.5±11.5 101.7±31.2†§║∞ 0.71±0.03 0.63±0.05§Ω 0.71±0.02 0.66±0.04‡∆ 0.61±0.07 0.47±0.07§║∞ 0.51±0.05 0.38±0.06§¤∞
HBSS (n = 14) Baseline Day 2 post-MI Day 28 post-MI 50.1±4.4 31.8±3.5* 21.4±6.4*§Ω 33.3±4.7 42.9±6.3* 82.5±26.0*‡Ω 66.7±6.3 62.9±7.9 103.4±25.5*§║∞ 0.73±0.02 0.67±0.04§Ω 0.71±0.02 0.70±0.01 0.63±0.03 0.46±0.09§║∞ 0.54±0.06 0.33±0.09§Ω
AWTd, anterior wall thickness in diastole; BMCs, bone marrow cells; EDV, end-diastolic volume; EF, ejection fraction; ESV, end-systolic volume; HBSS, Hank’s balanced salt solution; MI, myocardial infarction; PWTd, posterior wall thickness in diastole.* P<0.0001 vs baseline; P<0.01 vs baseline; # P<0.05 vs baseline; § P<0.0001 vs day 2 post-MI; P<0.01 vs day 2 post-MI; P<0.05 vs day 2 post-MI; P<0.001 vs young donor group; ¤ P<0.01 vs young donor group; P<0.05 vs young donor group; O P<0.001 vs young and middle-aged donor groups; 8 P<0.05 vs middle-aged donor group; and ? P<0.01 vs middle-aged donor group and HBSS control group.
Table 1: Recipient echocardiographic parameters before (day 2 post-MI) and after (day 28 post-MI) the implantation of BMCs from donors at different ages.