Commercial product Description References
Epidermal substitutes    
BioSeed-S™ Subconfluent autologous keratinocytes on a fibrin matrix [14-15]
CellSpray™ Noncultured autologous keratinocyte suspension -
Cryoskin™ Cryopreserved monolayer of noncultured allogeneic keratinocytes coating with silicone backing [16-17]
Epibase Cultured autologous keratinocytes [18-21]
Epicel® Cultured autologous keratinocytes from skin on petrolatum gauze backing [8,22-23]
Epidex™ Cultured autologous keratinocytes from the outer root sheath on silicone membrane [24-26]
Episkin™ Cultured keratinocytes on a collagen matrix [27-29]
Laserskin™ (Vivoderm™) Cultured autologous keratinocytes in a matrix of a hyaluronic acid ester [30-37]
LyphoDerm™ Freeze-dried lysate from cultured allogeneic epidermal keratinocytes into a hydrophilic gel [38]
Myskin™ Cultured autologous keratinocytes seeded on specially treated silicone sheet [39-40]
ReCell® Noncultured autologous keratinocyte suspension [41-45]
Suprathel® Absorbable, synthetic wound dressing with properties of natural epithelium [46-48]
  Dermal substitutes    
AlloDerm™ Allogeneic acellular dermal matrix [49-54]
Biobrane™ Porcine collagen chemically bound to silicone/nylon membrane [55-58]
Cymetra™ Micronized particulate acellular cadaveric dermal matrix [59]
Dermagen Allogeneic fibroblasts cultured in a collagenous sponge [60]
Dermagraft™ Allogeneic living human-derived fibroblast skin substitute [54,61-63]
Dermamatrix Allogeneic acellular human dermis [49-50]
EZ-Derm™ Acellular xenogeneic collagen matrix [64-65]
FortaFlex™ Acellular collagen matrix material derived from porcine small intestine submucosa -
Glyaderm® Acellular human dermis [66-67]
Graftjacket® Allogeneic human acellular pre-meshed dermis [68-70]
Hyalograft 3D™ Autologous dermal substitute including a matrix of a hyaluronic acid ester [30-31,71-72]
ICX-SKN Allogeneic dermal substitute with human dermal fibroblasts in human collagen matrix [73-74]
Integra® Nonliving extracellular matrix of collagen and chondroitin-6-sulfate with silicone backing [45,75-82]
Karoderm Allogeneic human acellular dermis -
Matriderm™ Acellular scaffold composed of elastin and collagen types I, III and V [83-88]
Oasis™ Acellular collagen matrix material derived porcine small intestinal submucosa [89-91]
Permacol Surgical Implant Acellular porcine dermis [92-94]
Repliform™ Acellular cadaveric human dermal allograft [95]
Strattice™ Acellular porcine dermis [96-99]
SureDerm Allogeneic acellular human lyophilized dermis [100-101]
TransCyte™ Polymer membrane and allogeneic neonatal human fibroblast cells on a nylon mesh coated with porcine dermal collagen and bonded to a polymer membrane (silicone) [102-106]
  Bilayer substitutes    
Apligraf® Allogeneic cultured human keratinocytes and fibroblasts in a bovine collagen sponge [107-109]
OrCel® Similar to Apligraf® [110-111]
PermaDerm™ Autologous keratinocytes seeded onto dermal substitute made with
autologous fibroblasts in bovine collagen matrix
[112-113]
PolyActive Autologous cultured keratinocytes and fibroblasts in elastomeric and biodegradable polyethylene oxide terephthalate/polybutylene terephthalate copolymer [114-117]
StrataGraft® Allogeneic dermis and epidermis generated from a progenitor cell line: neonatal immortalized keratinocytes (NIKS®) [118-119]
TissueTech™ Autologous dermal substitute Hyalograft 3D combined with an autologous epidermal replacement (Laserskin autograft) [31,120]
Table 1: Commercially available skin substitutes.