| Commercial product |
Description |
References |
| Epidermal substitutes |
|
|
| BioSeed-S™ |
Subconfluent autologous keratinocytes on a fibrin matrix |
[14-15] |
| CellSpray™ |
Noncultured autologous keratinocyte suspension |
- |
| Cryoskin™ |
Cryopreserved monolayer of noncultured allogeneic keratinocytes coating with silicone backing |
[16-17] |
| Epibase |
Cultured autologous keratinocytes |
[18-21] |
| Epicel® |
Cultured autologous keratinocytes from skin on petrolatum gauze backing |
[8,22-23] |
| Epidex™ |
Cultured autologous keratinocytes from the outer root sheath on silicone membrane |
[24-26] |
| Episkin™ |
Cultured keratinocytes on a collagen matrix |
[27-29] |
| Laserskin™ (Vivoderm™) |
Cultured autologous keratinocytes in a matrix of a hyaluronic acid ester |
[30-37] |
| LyphoDerm™ |
Freeze-dried lysate from cultured allogeneic epidermal keratinocytes into a hydrophilic gel |
[38] |
| Myskin™ |
Cultured autologous keratinocytes seeded on specially treated silicone sheet |
[39-40] |
| ReCell® |
Noncultured autologous keratinocyte suspension |
[41-45] |
| Suprathel® |
Absorbable, synthetic wound dressing with properties of natural epithelium |
[46-48] |
|
Dermal substitutes |
|
|
| AlloDerm™ |
Allogeneic acellular dermal matrix |
[49-54] |
| Biobrane™ |
Porcine collagen chemically bound to silicone/nylon membrane |
[55-58] |
| Cymetra™ |
Micronized particulate acellular cadaveric dermal matrix |
[59] |
| Dermagen |
Allogeneic fibroblasts cultured in a collagenous sponge |
[60] |
| Dermagraft™ |
Allogeneic living human-derived fibroblast skin substitute |
[54,61-63] |
| Dermamatrix |
Allogeneic acellular human dermis |
[49-50] |
| EZ-Derm™ |
Acellular xenogeneic collagen matrix |
[64-65] |
| FortaFlex™ |
Acellular collagen matrix material derived from porcine small intestine submucosa |
- |
| Glyaderm® |
Acellular human dermis |
[66-67] |
| Graftjacket® |
Allogeneic human acellular pre-meshed dermis |
[68-70] |
| Hyalograft 3D™ |
Autologous dermal substitute including a matrix of a hyaluronic acid ester |
[30-31,71-72] |
| ICX-SKN |
Allogeneic dermal substitute with human dermal fibroblasts in human collagen matrix |
[73-74] |
| Integra® |
Nonliving extracellular matrix of collagen and chondroitin-6-sulfate with silicone backing |
[45,75-82] |
| Karoderm |
Allogeneic human acellular dermis |
- |
| Matriderm™ |
Acellular scaffold composed of elastin and collagen types I, III and V |
[83-88] |
| Oasis™ |
Acellular collagen matrix material derived porcine small intestinal submucosa |
[89-91] |
| Permacol Surgical Implant |
Acellular porcine dermis |
[92-94] |
| Repliform™ |
Acellular cadaveric human dermal allograft |
[95] |
| Strattice™ |
Acellular porcine dermis |
[96-99] |
| SureDerm |
Allogeneic acellular human lyophilized dermis |
[100-101] |
| TransCyte™ |
Polymer membrane and allogeneic neonatal human fibroblast cells on a nylon mesh coated with porcine dermal collagen and bonded to a polymer membrane (silicone) |
[102-106] |
|
Bilayer substitutes |
|
|
| Apligraf® |
Allogeneic cultured human keratinocytes and fibroblasts in a bovine collagen sponge |
[107-109] |
| OrCel® |
Similar to Apligraf® |
[110-111] |
| PermaDerm™ |
Autologous keratinocytes seeded onto dermal substitute made with
autologous fibroblasts in bovine collagen matrix |
[112-113] |
| PolyActive |
Autologous cultured keratinocytes and fibroblasts in elastomeric and biodegradable polyethylene oxide terephthalate/polybutylene terephthalate copolymer |
[114-117] |
| StrataGraft® |
Allogeneic dermis and epidermis generated from a progenitor cell line: neonatal immortalized keratinocytes (NIKS®) |
[118-119] |
| TissueTech™ |
Autologous dermal substitute Hyalograft 3D combined with an autologous epidermal replacement (Laserskin autograft) |
[31,120] |
