Figure 5: Papilloma outgrowth in normal EIII/JC inbred rabbits after CRPVE1/161-169, 303-311, 245-253, 42-50, 149-157 or HPV16E7/82-90 epitope DNA vaccination. Four normal EIII/JC inbred rabbits immunized with each of the five epitope or an HPV16E7/82-90 epitope DNA vaccine were challenged with wtCRPV and coCRPV at four left and right back sites respectively. Significantly smaller papillomas were found in CRPVE1/42-50 and 303-311 epitope DNA vaccinated rabbits when compared with those in other three epitope DNA and HPV16E7/82-90 vaccinated rabbits challenged with both wtCRPV DNA (A) and coCRPV DNA (B) (P<0.01 vs. control group, unpaired student t test). No significant difference was found between these two CRPVE1/149-157, 245-253, 161-169 and HPV16E7/82-90 epitope vaccinated rabbits (P>0.05, unpaired student t test).