IgG2a/IgG1 ratioc

Preimmunized with:
 
Weekb
DENV1

DENV2
DENV3

DENV4

JEV
YFV
DENV2

 
0
64
2
64
1
-d
-
6
2048
16
512
8
-
-

Controla
6
512
16
64
16
-
-

JEVAX
0
1/2
1/4
1/64
1/2
1
-
6
16
2
8
2
1
-
Control
6
512
32
16
16
8
-
YFV
0
4
1/8
1
1/4
-
4
6
64
1
4
4
-
1
Control
6
512
32
16
16
-
8

aInoculated with PBS
bPeriod (week) after the first vaccination with the dengue tetravalent DNA vaccine. “0” indicates the time point just before the first vaccination
cThe ratio of IgG2a to IgG1 antibody titers against each of the viruses: DENV1–4, JEV and YFV
dNot tested.
Table 2: IgG isotype profi les of the antibodies induced in mice preimmunized with flavivirus antigens and then vaccinated with the dengue tetravalent DNA vaccine.