Days of vaccination 0 30 60 - - Days of bleeding 0 30 60 90 360 Mean value of total protein (g/dl) 7.65 7.393 7.87 8.3 8 Mean value of gamma globulin (g/dl) 0.98 1.222 1.2237 1.242 1.17 Mean value of anti-morphine antibody (g/dl) 0.735 0.9165 0.92775 0.9315 0.8775

Table 1: Changes in mean values of anti morphine anti-body, total protein and gamma globulin in 436 addicted volunteers in 360 days.