• Chronic infection can lead to cancer
Differences HPV HBV
  • Local infection at the mucosa
  • Attenuation of immune mechanism
  • Many viral subtypes
  • Viral entry occurs rapidly, but infected cell shows no inflammation
  • Virus elimination via natural cell clearance
  • Innate immune response, late induction of adaptive response (low antibody levels after long exposure to infection)
  • Natural immunity does not reliably prevent from infection
  • Systemic infection
  • Viral progression 1 to 6 months from infection to disease
  • Strong immune response
  • Neutralising antibodies and CTL activation
  • Immune mechanisms in subjects who recovered from HBV infection provide lifelong immunity
Table 1: Similarities and differences HBV and HPV infection.