Similarities Acceptable safety profile Need for enhanced protection Long persistence of protection needed to prevent new infections Strong immune priming needed Vaccination prevents from disease but not necessarily from infection Differences HPV HBV   Risk of re-infection or new infection Need of local protection with high antibody level at site of infection Need to prevent infection Antibodies migrate from serum to mucosa by transudation or exudation Role of B-memory and vaccine anamnestic response unknown up to now No serological correlate of protection identified   Serological correlate of protection identified Role of B cell memory established, protection observed in absence of circulating antibodies Immunocompromised patients are in need of higher doses and of booster dose

Table 3: Similarities and differences for HBV and HPV vaccines.