HPV

HBV

High and sustained antibody titres in serum correlate with high antibody titres in mucosa
Sustained protection
Cross-protection

Enhanced protection of high risk population
Longer persistence of high antibody levels
Less need for a booster

High neutralizing levels of antibody
Higher frequency of B-cell memory
Antibody persistence
Contributes to achieve needed immune profile to ensure protection

Table 4: Benefits of AS04 for the vaccines.