Value Vaccinated (n=41) Placebo (n=39)   Day 0 3rdmo 6th mo 12th mo Day 0 3rd mo 6th mo 12th mo ALT (IU/l) 26.95±10.67 26.98±14.25 27.79±18.15 25.37±13.03 28.62±13.89 25.05±17.79 23.85±10.95 27.63±17.37 Detectable HBV DNA (n%) 35 (85.4) NE 38 (92.7) 33 (80.5) 36 (94.7) NE 35 (89.7) 34 (89.5) Seroconversion anti-HBe (n%) 0 NE 0 1 (2.4) 0 NE 0 0 Seroconversion to anti-HBs (n%) 0 NE 2 (4.9) 3 (7.3) 0 NE 3 (7.7) 4 (10.3) NE= not evaluated at that time. All of the comparisons for the same values in the same time between two groups were not statistically significant (P>0.05)

Table 2: Comparison of virologic, serologic and biochemical values at the beginning of the study, at the end of the 6th and 12th months in vaccinated and placebo groups.