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Figure 2: The peptide binding to the HLA class II molecule. The peptides (shown in amber colour) predicted to a have very high affinity for the allele DRB1_130 and DRB1_0405 modeled on to the crystal structure (1A6A and 1BX2) based on the position of the peptide. Potential hydrogen bonds are shown in red colour. The highest binder peptide (A) IVRQRVIPV and (B) FRLMRTNFL are derived from the Ebola virus NP. |