Figure 7: Monoclonal antibody ablation of immune components during the induction or effector phases of immunity to JgD
Mice were immunized on day 0 and 21 with JgD vaccine in adjuvant or with adjuvant alone. Before the initial immunization or before the viral challenge as appropriate, select groups (n=7) of mice were treated with monoclonal antibodies to CD4, CD8, IFN-γ or control serum [6,18]. The survival is shown following zosteriform HSV-1 viral challenge. Ablating antibody may remain present during the challenge period.