Existing Vaccines Dosage Advantages Drawbacks
Hib - Haemophilus b
Conjugate Vaccine
(Tetanus Toxoid Conjugate)
ActHIB® - Sanofi-Pasteur
1 dose of 0.5ml contains 10 μg purified polysaccharide, 3 doses with 6 to 8 weeks of interval. (Intramuscular) Can be used in children as young as 2 months old - achieve high peak antibody concentration Only protects against type b, and does not offer coverage to emerging non-capsulated groups [11,33]
Haemophilus b conjugate Vaccine
(Diphtheria CRM197 Protein Conjugate)
HibTITER®- Wyeth Lederle
1 dose contains10 μg of purified Haemophilus b saccharide and 25 μg of CRM197 protein. 3 doses with 2 months interval. (Intramuscular) Achieve high peak antibody concentration, offer long term protection. Only protects against type b, and does not offer coverage to emerging non-capsulated groups [11].
Liquid PedvaxHIB®
[Haemophilus b Conjugate Vaccine
(Meningococcal Protein Conjugate)]- Merk
1 dose contains7.5 μg of Haemophilus b PRP (polysaccharide capsule), 125 μ of
N. meningitidisOMPC and 225 μg of aluminum (Intramuscular)
Provides the
earliest antibody levels thought to be protective against invasive
disease.
Only protects against type b, and does not offer coverage to emerging non-capsulated groups. Does not achieve high peak antibody concentration as the other two vaccines [11,34].
Table 2: Commercial available vaccines for H. influenzae available in the USA.