Figure 1b: ROC curve of increasing rate of tumor burden predicting mortality at progression according to the RECIST criteria. The area under the ROC curve was 0.73 (95% CI: 0.42, 1.00). Increases in the largest perpendicular diameters of at least 43% are predictive of mortality at progression with a sensitivity of 85% (58%, 96%) and a specificity of 50% (9%, 91%).