Table 1

Species Targeted	Virus Used	Disadvantages
Chimpanzees	HIV-1	Limited Availability of animal Costly approach
Macaques	SIV	Different envelope sequences as compared to HIV-1 Envelope epitopes were also different
Macaques	SHIV	The difference in the kinetics of the immune response when used as a vaccine when compared to HIV-1 immune response kinetics

Table 1: Problems using nonhuman primates during vaccine development.