Vaccine

Vaccine Components

Trial Result

VAX004
(AIDSVAX B/B)

Recombinant gp 120

No efficacy
seen

VAX003
(AIDSVAX B/E)

Recombinant gp 120

No efficacy
seen

STEP
(MRKAd5 HIV-1)

rAd5 (gag, pol, nef)

No efficacy +
Enhancement of infection

RV144
(ALVAC-HIV-1
AIDSVAX B/E)

Prime –
Subtype B and A/E
ALVAC-HIV-gag-pr-gp41-gp120 (canarypox vector)

Boost –
Subtypes B & E gp120 (subunit proteins)

Modest efficacy (31.2%)

HVTN 505

Prime-
Multiclade HIV-1 DNA plasmid (EnvA, EnvB, EnvC, gagB, polB, nefB)
Boost-
Recombinant adenovirus vector (Ad5 EnvA, EnvB, EnvC, gag/polB).

Under phase 2 studies [38]