Coating B2443     Titer SBA-15 SBA-16 1:500 P= 0,2310, not significant P= 0,3186, not significant 1:1.000 P= 0,2063, not significant P= 0,2524, not significant 1:2.000 P= 0,1494, not significant P= 0,5487, not significant 1:4.000 P= 0,0028, very significant P= 0,3148, not significant 1:8.000 P= 0,0018, very significant P= 0,1698, not significant 1:16.000 P= 0,0005, extremely significant P= 0,3667, not significant 1:32.000 P= 0,0003, extremely significant P= 0,2221, not significant Coating B4     Titer SBA-15 SBA-16 1:500 P= 0,0006, extremely significant P= 0,0005 extremely significant 1:1.000 P ≤ 0,0001, extremely significant P= 0,0003 extremely significant 1:2.000 P= 0,0002, extremely significant P= 0,0084, very significant 1:4.000 P= 0,0001, extremely significant P= 0,0027, very significant 1:8.000 P= 0,0004, extremely significant P= 0,0069, very significant 1:16.000 P= 0,1829, not significant P= 0,2112 , not significant 1:32.000 P= 0,0411, significant P= 0,1691, not significant Coating P2354     Titer SBA-15 SBA-16 1:500 P= 0,0040, very significant P= 0,0043, very significant 1:1.000 P ≤ 0,0001, extremely significant P= 0,0009, extremely significant 1:2.000 P ≤ 0,0001, extremely significant P ≤ 0,0001, extremely significant 1:4.000 P= 0,0004, extremely significant P= 0,0008, extremely significant 1:8.000 P ≤ 0,0001, extremely significant P ≤ 0,0001, extremely significant 1:16.000 P= 0,0003, extremely significant P= 0,0064, very significant 1:32.000 P= 0,0004, extremely significant P= 0,0005 extremely significant Coating C2135     Titer SBA-15 SBA-16 1:500 P= 0,0464, significant P= 0,0186, significant 1:1.000 P= 0,0008, extremely significant P ≤ 0,0001, extremely significant 1:2.000 P= 0,0579, not significant P= 0,0129, significant 1:4.000 P= 0,0062, very significant P ≤ 0,0001, extremely significant 1:8.000 P= 0,0071, very significant P= 0,0033, very significant 1:16.000 P= 0,0151, significant P ≤ 0,0001, extremely significant 1:32.000 P= 0,2335, not significant P= 0,0635, not significant Coating P2498     Titer SBA-15 SBA-16 1:500 P= 0,0060, very significant P ≤ 0,0001, extremely significant 1:1.000 P= 0,0004, extremely significant P= 0,0002, extremely significant 1:2.000 P= 0,0013, very significant P= 0,0004, extremely significant 1:4.000 P= 0,0003, extremely significant P= 0,0063, very significant 1:8.000 P= 0,0046, very significant P= 0,0129, significant 1:16.000 P= 0,0449, significant P= 0,0167, significant 1:32.000 P= 0,0108, significant P= 0,0205, significant Coating YUSA     Titer SBA-15 SBA-16 1:500 P ≤ 0,0001, extremely significant P= 0,0851, not significant 1:1.000 P= 0,0002, extremely significant P= 0,0831, not significant 1:2.000 P=  0,0159, significant P= 0,1733, not significant 1:4.000 P ≤ 0,0001, extremely significant P= 0,1084, not significant 1:8.000 P ≤ 0,0001, extremely significant P= 0,0011, very significant 1:16.000 P ≤ 0,0001, extremely significant P= 0,0007, very significant 1:32.000 P ≤ 0,0001, extremely significant P= 0,5000, not significant

Table 4: Statistic anlalysis of ELISA test using the Tukey’s test one way comparing the absorbance of sera obtained from mice immunized with OMV and ajuvant OMV + SBa-15 and OMV + SBa16.