Vaccine composition per 0.5 mL Vaccine samples
3.75 µg HA 7.5 µg HA 15 µg HA
Hemagglutinin, µg 3.75 ± 0.5 7.5 ± 1.0 15.0 ± 2.0
Aluminum hydroxide (Al3+), mg 0.125 ± 0.025 0.25 ± 0.05 0.5 ± 0.1
Thimerosal, µg 50 ± 7 50 ± 7 50 ± 7
PBS*, mL up to 0.5 mL up to 0.5 mL up to 0.5 mL
*containing NaCl (Sigma, St. Louis, MO, USA) 8.7 g; Na2HPO4.7H2O (Sigma) 1.88 g; NaH2PO4.2H2O (Sigma) 0.46 g; water to 1 L.
Table 1: Composition of the Refluvac® vaccine samples.