| Virus |
Virus dose, log10 EID50/ferret |
Day p.i. |
Virus load (log10 PFU/g) |
Lung lesions score: individual (average) |
| Lung |
Nose |
| VN/H5N2 LAIV |
6.0 |
3 |
0 |
0 |
0; 1; 0 (0.3) |
| 5 |
0 |
0 |
2; 2; 2 (2.0) |
| 7.0 |
3 |
0 |
0 |
0; 0; 0 (0) |
| 5 |
0 |
0 |
3; 2; 3 (2.7) |
| VN/H5N1-RG LAIV |
6.0 |
3 |
0 |
0 |
0; 0; 0 (0) |
| 5 |
0 |
0 |
0; 0; 2 (0.7) |
| 7.0 |
3 |
0 |
0 |
0; 0; 2 (0.7) |
| 5 |
0 |
0 |
0; 0; 2 (0.7) |
| t/T/H5N2 LAIV |
6.0 |
3 |
0 |
0 |
2; 0; 0 (0.7) |
| 5 |
0 |
0 |
0; 0; 0 (0) |
| 7.0 |
3 |
0 |
0 |
0; 2; 2 (1.3) |
| 5 |
0 |
0 |
0; 0; 2 (0.7) |
| A/turkey/Turkey/1/2005 (H5N1) HPAIV |
7.0 |
3 |
4.15 |
4.24 |
5; 5; 5 (5.0) |
| 5 |
3.89 |
4.17 |
5; 5; 5 (5.0) |
| A/Vietnam/1194/2004 (H5N1) HPAIV |
7.0 |
3 |
4.36 |
4.20 |
5; 5; 5 (5.0) |
| 5 |
4.25 |
3.89 |
5; 5; 5 (5.0) |
| A/17/California/2009/38 (H1N1) LAIV |
7.0 |
3 |
0 |
0 |
0; 0; 0 (0) |
| 5 |
0 |
0 |
0; 0; 0 (0) |
| Placebo (PBS) |
NO |
3 |
0 |
0 |
0; 0; 0 (0) |
| 5 |
0 |
0 |
0; 0; 0 (0) |
Virus load was determined in tested samples by plaque titration in MDCK cells. Three animals in each group were tested. Histopathological parameters were scored as:
0 - absent (no visible changes), 1 - minimal, 2 - slight, 3 - moderate, 4 - strong, 5 - severe. |
