| Test article |
Week post vaccination |
H5N1 antigen for HAI test (GMT1) |
| Vietnam2 (clade 1) |
Indonesia3 (clade 2.1) |
Turkey4 (clade 2.2) |
Bar-h goose5 (clade 2.2) |
W.swan6 (clade 2.2) |
Anhui7 (clade 2.3) |
| VN/H5N2 LAIV (clade 1) |
0 |
10.0 |
10.0 |
10.0 |
10.0 |
10.0 |
10.0 |
| 4 |
40.0 |
11.2 |
10.0 |
10.0 |
14.1 |
10.0 |
| 6 |
403.1 |
10.0 |
20.0 |
20.0 |
31.8 |
17.8 |
| 6/4 |
10.18 |
1.2 |
2.0 |
2.0 |
2.3 |
1.8 |
| VN/H5N1-RG LAIV (clade 1) |
0 |
10.0 |
10.0 |
10.0 |
10.0 |
10.0 |
10.0 |
| 4 |
50.4 |
11.2 |
10.0 |
10.0 |
22.5 |
10.0 |
| 6 |
285.1 |
35.6 |
14.1 |
14.1 |
127.0 |
17.8 |
| 6/4 |
5.7 |
3.2 |
1.4 |
1.4 |
5.6 |
1.8 |
| t/T/H5N2 LAIV
(clade 2.2) |
0 |
10.0 |
10.0 |
10.0 |
10.0 |
10.0 |
10.0 |
| 4 |
127.0 |
10.0 |
12.6 |
14.1 |
10.0 |
10.0 |
| 6 |
508.0 |
44.9 |
127.0 |
113.1 |
40.0 |
22.5 |
| 6/4 |
4.01 |
4.5 |
10.1 |
8.0 |
4.0 |
2.3 |
| PBS |
0 |
10.0 |
10.0 |
10.0 |
10.0 |
10.0 |
10.0 |
| 4 |
10.0 |
10.0 |
10.0 |
10.0 |
10.0 |
10.0 |
| 6 |
10.0 |
10.0 |
10.0 |
10.0 |
10.0 |
10.0 |
| 6/4 |
1.0 |
1.0 |
1.0 |
1.0 |
1.0 |
1.0 |
|
| Vaccination dose: 7.0 log10 ID50/ferret. Blood samples were collected at day 28 (week 4) and at day 42 (week 6) post immunization.
1Geometric mean titer; each group contained six animals; 2A/Vietnam/1203/04 (H5N1); 3A/Indonesia/5/05 (H5N1); 4A/turkey/Turkey/1/05 (H5N1); 5A/bar-headed goose/
Mongolia/1/2005 (H5N1); 6A/whooper swan/Mongolia/244/05 (H5N1); 7A/Anhui/1/05 (H5N1). 8A fourfold or greater rise in titer of antibodies against virus hemagglutinin in
sera of ferrets between the first (week 4) and second sample (week 6) was considered as seroconversion. |
| Table 8: Immunogenicity of H5N2 LAIV candidates in experiments on ferrets. |
