| LAIV immunization, (7 log10EID50/ferret)/ Placebo control |
H5N1 HPAIV challenge virus/PBS load1 |
| A/Vietnam/1194/2004 |
A/turkey/Turkey/1/2005 |
PBS |
| Lungs (D3) |
Nose (D3) |
Nasal wash (D3 / D5)3 |
Lungs (D3) |
Nose (D3) |
Nasal wash (D3 / D5) |
Lungs (D3) |
Nose (D3) |
Nasal wash (D3 / D5) |
| VN/H5N2 LAIV |
0 |
1.40 |
2.80 / 0 |
nd |
nd |
nd |
0 |
0 |
0 |
| VN/H5N1-RG LAIV |
0 |
1.52 |
2.88 / 0 |
nd |
nd |
nd |
0 |
0 |
0 |
| t/T/H5N2 LAIV |
nd2 |
nd |
nd |
0 |
1.45 |
2.23 / 0 |
0 |
0 |
0 |
| Placebo (PBS) |
4.86 |
5.10 |
5.96 / 4.84 |
4.82 |
4.96 |
5.80 / 4.53 |
0 |
0 |
0 |
1Virus load expressed in log10 PFU/g for lung and nasal turbinates supernatants or log10 PFU/ml for nasal washes;
2nd - not done, challenge with heterogeneous H5N1-HPAIV was not performed;
3D3, D5 - day post-infection with challenged H5N1-HPAIV or placebo inoculation. |
