COPD stage Before vaccination After 3 months After 6 months After 12 months H1N1 H3N2 B H1N1 H3N2 B H1N1 H3N2 B H1N1 H3N2 B 1(n=2) 55.0 ± 0 77.5 ± 2.5 222.5 ± 17.5 442.5 ± 37.5 2200 ± 120.0 1180 ± 140.0 442.5 ± 37.5 2200 ± 120.0 1160 222.5 ± 17.5 2200 ± 120.0 660.0 ± 20.0 2(n=21) 444.52 ± 15.71 1106.2 ± 39.93 445.0 ± 15.89 993.3 ± 32.67 882.9 ± 24.81 1100 ± 16.47** 881.4 ± 31.95 1132 ± 33.58 556.4 ± 11.16 994.5 ± 33.4 1149 ± 34.31 771.2 ± 16.32* 3 (n=14) 773.93 ± 43.87 1141.8 ± 58.6 774.6 ± 24.56 557.8 ± 14.7 1125 ± 39.27 777.8 ± 17.14 1139 ± 88.86 1104 ± 27.45 887.9 ± 28.24 1149 ± 88.34 1145 ± 46.73 779.6 ± 21.35 4 (n=4) 330.0 ± 16.83 887.5 ± 41.91 1102 ± 72.84 550.0 ± 30.0 550.0 ± 30.0 1120 ± 40.0 337.5 ± 15.48 555.0 ± 15.0 1133 ± 70.4 225.0 ± 5.0 440.0 ± 14.14 1135 ± 68.98 Total (n=41) 551.22 ± 16.96 1111.7 ± 28.73 559.6 ± 13.48 773.0 ± 16.88* 1105 ± 20.68 1100 ± 13.99*** 994.9 ± 34.23 1118 ± 20.34 779.6 ± 13.37 1103 ± 34.55* 1140 ± 24.35* 779.8 ± 12.77* Note: * - р<0.05; ** - p<0.01; *** - p<0.001 – as compared to baseline values

Table 3: Changes of post-vaccination levels of IgG antibodies to influenza virus strains A/H1N1, A/H3N2, B in patients with COPD