Figure 2: Immunohistochemical staining patterns of glioblastoma multiforme (GBM) formalin-fixed, paraffin embedded tissue specimens for survivin. (A) GBM showing predominant nuclear staining for survivin. (B) GBM with mostly cytoplasmic survivin expression and lack of nuclear staining. (C) Representative high magnification from a third GBM showing a cell with simultaneous cytoplasmic and nuclear survivin expression. [A, B 200x; C, 400x; anti-survivin clone 12C4 (Dako North America, Inc. Carpinteria, CA)].