Animal ID Lung Liver Kidney
PBS OMVs PBS OMVs PBS OMVs
1 3 0 3 1 3 0
2 1 0 2 0 3 1
3 2 0 2 1 3 0
4 2 0 3 0 3 0
5 2 0 3 0 3 1
6 2 0 3 0 3 0
7 3 0 2 0 3 0
8 0 0 0 0 0 0
Average score 1.875 0 2.25 0.25 2.625 0.25
Table 2: Prophylactic efficacy of Leptospira OMVs evaluated on the basis of histopathological lesions score in various organs. The pulmonary, hepatic and renal inflammatory lesions in hamsters were graded on a scale of severity; 0=within normal limit, 1=mild, 2=moderate, and 3=severe.