Figure 1: Met6 peptide vaccines induce protective responses in mice against disseminated candidiasis. Vaccination with Met6 peptide by the dendritic cell approach induced significant protection against experimental disseminated candidiasis in mice, as compared to control groups. (A) Vaccinated mice challenged with a lethal dose of a prototypical strain of C. albicans (SC5314) had a significant prolonged survival time as compared to control mice that received DCs or DPBS (P<0.01). (B) Consistently with survival data, immunized mice had greatly reduced or non-detectable CFUs in their kidneys (P<0.001) as compared to control mice. (C) Antibody is responsible for protection against disseminated candidiasis. Enhanced protection against disseminated C. albicans infection was observed in mice that received serum from mice immunized with the Met6 peptide as compared to animals that received control materials. Note that the mice immunized with Met6 peptide, which were used as positive controls for protection, had similar survival curve as the naïve mice that received the immune serum. Importantly, absorption with C. albicans before transfer also removed the protective value of immune serum.