| Vaccines against |
Routes of immunization |
Active component(s) |
Doses |
Names of Licensed products (manufacturers) |
Target population
(age of vaccinees) |
References |
| Cholera |
| Killed whole-cell/recombinant cholera toxin B-subunit vaccine (WC/rBS) |
Oral |
Mixture of 1011 heat-killed or formalin-killed. choleraeO1 of classical and El Tor biotypes and Inaba and Ogawa serotypes +1 mg CT B subunit |
2 |
Dukoral™(Crucell/SBL). |
Children, adult |
[10,11] |
| CVD 103- HgR recombinant live attenuated vaccine |
Oral |
A ∆ctxA derivative of classical Inaba strain V. cholera 569B (CVD 103) and an Hg++ resistance gene introduced into the Hemolysin A locus of the chromosome. 108–109cfu |
1 |
Berna, Swiss Serum and Vaccine Institute as Orachol (Europe), or Mutacol (North America)* |
Children, adult |
[13] |
| Killed whole cell (WC) bivalent vaccine |
Oral |
Inactivated V. cholerae bacteria (Same O1composition as above + 5 X 1010 formalin-killed O139 bacteria) |
2 |
Shancol (in India) mORC-Vax (in Vietnam) |
Children, adult |
[15] |
| Typhoid |
| Live attenuated Ty21a |
Oral |
Vi negative mutantstrain of
S. Typhi |
3 |
Vivotif (Berna Biotech) |
Children>2yr, adults |
[22,23] |
| Vi polysaccharide |
Parenteral |
Purified Vi capsular polysaccharide (CPS) |
1 |
Typhim Vi (Sanofi Pasteur)Typherix (GSK) TypBar (Bharat Biotech); Shantyph
(Shantha Biotech);Typho-Vi (BioMed) |
Children>2yr, adults |
[24,25] |
Conjugate vaccine
(Vi-TT) |
Parenteral |
Vi antigen is coupled to tetanus toxoid protein |
2 |
Peda-typhTM,(BioMed) |
Children < 2 yr |
|
| Multivalent combination vaccines |
Parenteral |
Combined Vi CPS and inactivated hepatitis A virus grown in human diploid cells and adsorbed onto aluminum hydroxide. |
2 |
HepatyrixTM, (GSK); ViatimTM, (Aventis Pasteur) |
adults and adolescents >15 yrs |
[36] |
| Rotavirus diarrhea |
| Pentavalent human-bovine reassortant WC3 vaccine |
Oral |
Bovine WC 3 reassortant viruses carrying G1, G2, G3 andG4 of P(8) RNA segment of human rotavirus |
3 |
RotaTeq™(Merck Vaccines, USA) |
Young infants |
[50] |
| Monovalent RIX-4414 human rotavirus strain |
Oral |
A G1 P [8] rotavirus isolated from a human infant that evoked neutralizing antibodies to rotaviruses of G types 1-4. |
2 |
Rotarix™(GSK Biologicals) |
Young infants |
[53] |
