| Th1/Th2 balance |
Objective |
Results |
References |
| Th1 bias |
Studymechanism of stress with cognitive deficit |
Th1-type cytokine correlates to a better performance |
Palumboa et al. [9] |
| Th1 bias |
Study association of Glatiramerof adult neurogenesis |
Glatiramer induce Th1bias
following increasing neurogenesis |
Palumboa et al., He et al. [9,13] |
| Th1 bias |
Study association of exercise of neurogenesis |
Moderate exercise producesTh1-like cytokine |
Baum et al. [11] |
| Th1 bias |
Study association of A(H1N1) Vaccination of neurogenesis |
A(H1N1) Vaccination causes Th1-like immune response |
Xia et al. [10] |
| Th1 bias |
Adaptive immune responseincreases hippocampalproliferation |
A rheumatoid arthritismodel,
Th1-dependent local inflammation |
Wolf et al. [5] |
| Th2 bias |
Study the effect of zinc on Th1/Th2 ratio in elderly individuals |
Decrease of Th1/Th2 ratio with aging |
Kahmann et al. [24] |
| Th2 bias |
Altered cytokine production in the elderly |
Decrease of Th1/Th2 ratio with aging |
Rink et al. [22] |
| Th2 bias |
Shift toward destructive Th2 inflammation in brain |
T helper type 2 (Th2) in choroidplexus inflammation with aging |
Baruch et al. [36] |
| Th2 bias |
Th2 bias at the maternal/fetal interface in pregnancy |
Decrease of neurogenesis in pregnancy related in Th2 bias |
Piao et al. [15]
Rolls et al. [14] |
