Immunogen
Groups
The first immuni-zation dose
The second immuni-zation dose
The mode of
S. pneumoniaе
infection
Number of animals
PSPF + adjuvant
1
5 µg/mouse
2.5 µg/mouse
intraperitoneally
10
intranasally
10
2
10 µg/mouse
5 µg/mouse
intraperitoneally
10
intranasally
10
3
20 µg/mouse
10 µg/mouse
intraperitoneally
10
intranasally
10
Adjuvant only
4
No PSPF(control group)
intraperitoneally
10
intranasally
10
z
5
1 vial/8 mice
1vial /16 mice
intraperitoneally
10
intranasally
10
Table 2:
Scheme of immunization.
