Disease Global estimated prevalence Global estimated deaths, 2014 Vaccine type Dose up to 35 months of age Averted deaths from immunization up to 2014 Major challenges and issues in immunization References
Poliomyelitis 359 reported cases except endemicity in Pakistan and Afghanistan with estimate 200 000 new cases every year NA Inactivated poliovirus (IPV) 3 More than 13 million people Political instability, insecurity and other anecdotes

-Weak country leadership commitment, local accountability and stewardship

-Weak capacity of health workers at all levels
[2]
Measles, Mumps and Rubella 18.7 million infants worldwide 114 900 measles deaths globally measles-mumps-rubella (MMR), 1 2 to 3 million deaths per year Weak logistics and fragmentation of planning

-Unproductive immunization data management and use  to inform programme innovations
[1,29]
Varicella 4.2 million 4200 deaths varicella-zoster virus (VZB), 1 2.5 million child deaths per year Shortages cold  supply chain management and logistics systems of vaccines including other essential commodities

-Limited healthcare service delivery
[2,4]
Hepatitis B 240 million people 780 000- 1 million deaths/year hepatitis B virus (HBV), 3 3.7 million future deaths  per year
Influenza b 3 to 5 million cases 250 000 to 500 000 deaths Haemophilus influenza type b (Hib) 3 NA Limited immunization spots and outreach sites
-Fragile communication strategies at all levels
[1,4]
Diphtheria, Tenanus and Pertussis 18.7 million infants 2 to 3 million deaths every year Diphtheria, Tetanus and acellular Tertussis (DTaP) vaccine 4
and at 13-15 years old)
2.5 million child deaths every year Scarce availability of vaccines storage capacity at all levels in most countries,

-Lack of funding for vaccine distribution in most remotes rural settings

-Health system dysfunctionment
[1,4]
Table 1: Major challenges in attaining national immunization coverage targets in WHO-AFRO countries.