Figure 4: Pre (a) and post (b) vaccination IFN-? synthesis. PBMC were collected before (T0; n=7 COPD subjects and 10 healthy controls) and after (T1; n=19 COPD subjects and 12 healthy controls) vaccination and cultured in vitro for five days in the presence or absence of influenza vaccine. Results are shown as median IQ. P values refer to the comparison between COPD patients and healthy controls.