Figure 2: Histopathology and immunohistochemistry of the liver during the transition period. No cellular abnormalities were found in any of hepatocytes 3 weeks before parturition (A). However, the hepatocytes at parturition (wk 0) (B) contain some lipid drops in cytosol, and the cells after 3 weeks parturition (C) turn opacificated severely and cellular membranes are indistinct (HE staining).