Dose (mg/mL) |
Parameter |
Parameter Estimate |
Standard error |
P valuea |
0 |
β0b |
8.543 |
0.126 |
<0.0001 |
0 |
β1c |
0.249 |
0.024 |
<0.0001 |
0 |
β2d |
-0.007 |
0.001 |
<0.0001 |
|
Time to maxe |
18.6 |
|
|
|
Value at maxf |
10.9 |
|
|
0.3 |
β0 |
8.358 |
0.130 |
<0.0001 |
0.3 |
β1 |
0.242 |
0.025 |
<0.0001 |
0.3 |
β2 |
-0.008 |
0.001 |
<0.0001 |
|
Time to max |
14.07 |
|
|
|
Value at max |
10.06 |
|
|
0.6 |
β0 |
8.285 |
0.139 |
<0.0001 |
0.6 |
β1 |
0.211 |
0.027 |
<0.0001 |
0.6 |
β2 |
-0.007 |
0.001 |
<0.0001 |
|
Time to max |
13.31 |
|
|
|
Value at max |
9.69 |
|
|
1.2 |
β0 |
8.280 |
0.181 |
<0.0001 |
1.2 |
β1 |
0.091 |
0.036 |
0.0136 |
1.2 |
β2 |
-0.004 |
0.001 |
0.0049 |
|
Time to max |
10.68 |
|
|
|
Value at max |
8.76 |
|
|
2.4 |
β0 |
8.690 |
0.549 |
<0.0001 |
2.4 |
β1 |
-0.188 |
0.107 |
0.1053 |
2.4 |
β2 |
-0.005 |
0.004 |
0.2034 |
|
Time to maxg |
-16.9 |
|
|
|
Value at maxg |
10.28 |
|
|
a Significance of parameter estimates represents appropriate fit of model (Y = β0
+ β1 x +β2 x2 + ε1) to data. b β0 represents y-intercept at time of inoculation; c β1
represents the rate of bacterial growth over time; d β2 represents point of inflection
where growth reached its maximum at a specific time; ε1 represents the random
error; e Time to max = time (h) when maximal growth was achieved; f Value at max
= amount of growth (estimated log CFU) at the time when maximal growth was
achieved; g for 2.4mg/mL dose, the time to maximum growth and its value for this
treatment should be interpreted with caution due to the lack of fit indicating that the
reduced model did not fit the data for 2.4 mg/mL PGF2α treatment. The lack of fit at
this specific concentration relates to the continuous decrease in bacterial growth
associated with the bactericidal effects of 2.4 mg/mL PGF2α treatment. |