Animals Retina Optic nerve head   Nerve fiber layer Muller cell processes Outer limiting membrane region Inner layer towards inner limiting membrane Pre-lamina region Lamina cribrosa region Post-lamina region mouse (data from reference 39) 0 0 0 0 0 not existent + Glaucoma mouse (n=18) 0 0 0 0 0 not existent + RCS +/- rat (n=12) + 0 0 + + + + RCS -/- rat (n=14) + 0 e 0 l (+) ++ + + + European mix breed and Abyssinian cat (n=6) + 0 0 ++ + + + RP Abyssinian cat (n=8) + e 0 l (+) 0 ++ e + l ++ e + l ++ + pig (n=5) ++ (+) 0 ++ + + + cow (n=4) ++ (+) 0 ++ + + + cynomolgus monkey (n=12) ++ 0 0 ++ + + + Glaucoma cynomolgus and rhesus monkey (n=7) ++ 0 0 +++ + + ++

Table 1: Semiquantitative evaluation of alphaB-crystallin distribution in the retina and optic nerve head of various animals (n= number of eyes evaluated). 0 = no staining; (+) = single or inconsistent staining; + = consistent mild staining; ++ = consistent moderate staining; +++ = consistent strong staining. e = early stages of disease, l = late stages of disease.