*MIC90 Bacteriostatica Bactericidalb Eradicationc **AUC24h/MIC = 80 1 1 1.46 1.9 2.48 2 2 2.91 3.8 4.96 4 4 5.82 7.6 9.92 *MIC90=minimum inhibitory concentration (μg/mL) for 90% isolates; AUC24h/MIC: ratio of in vivo AUC (0-24h) to in vitro MIC. a,b,cModelled AUC24h/MIC values for bacteriostatic activity (32 h), for bactericidal activity (47h) and for bacterial eradication (4 log inhibition) = 61 h; ** Recommended AUC24h/MIC value for clinical efficacy of aminoglycosides.

Table 4: Estimated daily dosage (mg/kg) of gentamicin for intravenous administration in buffalo calves.