Figure 3: Body weight of ovariectomized rats that received a Silastic tubing implant with and without estradiol. Rats were ovariectomized and received (A) an empty Silastic tubing implant, (B) no implant, (C) Silastic tubing with 3mg estradiol, (D) Silastic tubing with 4mg estradiol, and (E) Silastic tubing with 5mg estradiol. Removal of endogenous estradiol results in a significant (p<0.0001) change of body weight over time (n=7-8 for each group), according to one-way ANOVA, followed by a Tukey-Kramer multiple comparisons test. Rats treated with estradiol maintained a relative constant body weight through the 4 weeks of the study. OVX+SE n=7; OVX+S3 n=8; OVX+S4 n=8; OVX+S5 n=8. Each plot represents one animal.