| Genome |
Family |
Genus |
Species/Strain/Vector |
| DNA |
| ds |
Adenoviridae Poxviridae |
Mastadenovirus
Aviadenovirus
Orthopoxvirus |
Ad serotype 5 and several derivatives in experimental settings and in clinical trials.
Conditionally replicating vectors based on canine adenovirus
Replication-deficient vector CELO
Replication-competent vectors based on Vaccinia Strains WR and Wyeth. |
| ds |
Parvoviridae |
Parvovirus |
Live autonomous rodent parvovirus H-1.
Both live virus and replicons of minute virus mice.
Replicons of retargeted feline panleukopenia virus. |
| RNA |
| ds |
Reoviridae |
Orhtoreovirus |
Live reovirus type 3 strain Dearing (T3D) in both pre-clinical
experiments and in clinical trials. |
| ss |
Orthomyxoviridae Paramyxomaviri
dae |
Influenza virus A
Avulavirus |
Replication-competent NS1 deleted influenza A.
Experimental therapy in several cancer models using live attenuated
Newcastle disease virus strains such as 73-T, Ulster and Italian.
Clinical trials with the live attenuated PV701 and MTH-68/H strains of Newcastle disease virus. |
| DNA |
| ss |
Rhabdoviridae
Coronaviridae Picarnaviridae Togarviridae Retroviridae |
Respirovirus
Rubulavirus
Vesiculoviurs
Coronavirus
Enterovirus
Alphavirus
Lentivirus |
Replication-deficient vectors based on Sendai virus
Live mumps virus in experimental settings and in a clinical trial to treat ovarian cancer. Non-oncolytic replication-competent vectors based on simian virus 5.
Live attenuated vesicular stomatitis virus and recombinant derivatives.
In vitrooncolytic activity of retargeted replication-competent vectorsbased on feline coronavirus and murine hepatitis virus.
Live echovirus type 1.
Live attenuated poliovirus and bovine enterovirus in preclinical testing
Both replication-deficient and replication-competent MoMLV
vectors also used clinical trials.
Replication-deficient vectors based on HIV-1. |
