| Mechanism |
Examples |
| Direct cell lysis due to viral replication |
Adenoviruses Herpes simplex viruses |
| Direct cytotoxicity of viral protein |
Adenovirus E4ORF4 |
Induction of antitumoral immunity
*Nonspecific (e.g., TNF)
*Specific (e.g., CTL response) |
Adenovirus (E1A)
Herpes simplex virus |
Sensitization to chemotherapy and
radiation therapy |
Adenovirus (E1A)
Adenovirus (AdTK-RC) |
| Transgene expression |
Herpes simplex virus (rRp450)
Vaccinia virus (GM-CSF) |
