Vector Immunogenicity Long-term expression Transduction of Dividing (D) or Non-dividing (ND) cells
AV Moderate-severe No D
AAV No-mild Yes D and ND
Disabled lentivirus Mild-moderate Yes D and ND
Retrovirus Mild-moderate No D
Naked Plasmid No-mild No ND
Lipids No-moderate No ND
Table1: Characteristics of viral vectors used in corneal gene therapy.