| Corneal pathologic condition |
Vectors tested |
Genetic material |
Model |
Delivery route |
Effect on pathology resolution |
| Graft rejection |
AV, plasmids |
Cytotoxic T lymphocyte associated antigen 4, Inducible T-cell co-stimulator, Interleukin (IL)-10 antagonist, Interleukin-4 |
Mice, Rat, Sheep, Ex vivo |
IV, IP, Gene-gun |
+/- |
| Wound healing |
AV, AAV, retrovirus, Nanoparticles |
Decorin, Soluble type II TGFβ receptor, Tissue plasminogen activator |
Mice, Rat, Rabbit, Ex vivo, In vitro |
IM, Topical, Intrastromal, Intracameral, Electroporation |
+, +/-, - |
| Chemical burn |
AV, AAV, plasmids |
Decorin, SMAD7, Peroxisome proliferator activated receptor γ |
Mice, Rabbit |
Topical |
+, +/- |
| Haze and Fibrosis |
AV, AAV, plasmids, retrovirus. Nanoparticles |
Decorin, SMAD7, Peroxisome proliferator activated receptor γ, Soluble type II TGFβ receptor, BMP7, Herpes simplex virus thymidine kinase, Dominant negative cyclin G1 |
Rabbit, Ex vivo, In vitro |
Topical |
+, +/-, - |
| Neovascularization |
AV, AAV, plasmids, lentivirus |
Decorin, Vascular endothelial growth factor elated FLT-1, FLT23K, FLT24K, Endostsin, Kringle 5 plasminogen, Angistatin, IL-2, IL-10 |
Mice, Rat, Rabbit, Monkey, In vitro |
IM, Topical, Intrastromal, Intracameral, Electroporation |
+, +/-, - |
|
