Means at Baseline
(Std Dev)		 Means at Week 4
(Std Dev)		 Means at Week 8
(Std Dev)		 Percent Difference in Means
(Baseline to Week 4)		 Percent Difference in Means
(Week 4 to Week 8)		 Percent Difference in Means
(Baseline to Week 8)
Pain NRS            
Pain now 4.89
(1.69)		 4.33
(2.60)		 3.11
(1.45)		 11.36%*
p = 0.81		 28.21%*
p = 0.15		 36.36%*
p = 0.04**
Pain avg 5.67
(0.87)		 5.11
(1.45)		 4.56
(1.13)		 9.80%
p = 0.32		 10.87%*
p = 0.39		 19.61%*
p = 0.04**
Pain worst 7.67
(1.00)		 7.11
(1.45)		 6.67
(1.00)		 7.25%
p = 0.26		 5.80%
p = 0.41		 13.04%*
p = 0.05
Stress NRS^            
Stress now 3.56
(2.19)		 3.33
(2.00)		 4.33
(1.66)		 6.46%
p = 0.73		 -30.03%*
p = 0.20		 -21.63%
p = 0.32
FIQR Total 60.98
(6.55)		 49.74
(15.21)		 49.69
(7.20)		 18.43%*
p = 0.04**		 0.10%
p = 0.59		 18.51%*
p = 0.01**
FIQR Symptom
Subscale Components^		            
Pain 6.44
(0.88)		 5.00
(2.00)		 5.11
(1.691)		 22.36%
p = 0.09		 -2.20%
p = 0.83		 20.65%
p = 0.06
Energy 7.11
(2.15)		 6.67
(1.80)		 6.11
(2.21)		 6.19%
p = 0.33		 8.40%
p = 0.60		 14.06%
p = 0.34
Stiffness 7.44
(1.13)		 5.67
(2.45)		 5.44
(2.19)		 23.79%
p = 0.02**		 4.06%
p = 0.48		 26.88%
p = 0.03**
Sleep 8.33
(1.73)		 7.78
(1.20)		 6.56
(1.59)		 6.60%
p = 0.35		 15.68%
p = 0.20		 21.25%
p = 0.08
Depression 6.56
(1.81)		 4.78
(1.86)		 6.11
(2.47)		 27.13%
p = 0.04**		 -27.82%
p = 0.29		 6.86%
p = 0.57
Memory problems 7.33
(2.18)		 6.67
(2.29)		 5.78
(1.48)		 9.00%
p = 0.35		 13.34%
p = 0.22		 21.15%
p = 0.06
Anxiety 5.78
(2.77)		 5.00
(1.80)		 4.33
(2.12)		 8.26%
p = 0.40		 21.38%
p = 0.34		 27.88%
p = 0.02**
Tenderness to touch 6.78
(1.99)		 6.22
(2.64)		 4.98
(2.47)		 8.26%
p = 0.53		 21.38%
p = 0.31		 27.88%
p = 0.02**
Balance problems 4.44
(2.46)		 3.67
(2.87)		 3.22
(1.56)		 17.34%
p = 0.36		 12.26%
p = 0.86		 27.48%
p = 0.20
Sensitivity to external stimuli (light, noise, odors, cold) 6.56
(2.65)		 4.33
(1.73)		 5.22
(2.17)		 33.99%
p = 0.03**		 -20.55%
p = 0.17		 20.43%
p = 0.14
DSI^            
FREQ 20.44
(5.29)		 19.44
(7.14)		 22.11
(8.89)		 4.89%
p = 0.59		 -13.73%
p = 0.18		 -8.17%
p = 0.41
SUM  58.89
(30.51)		 53.00
(35.91)		 54.22
(29.27)		 10.00%
p = 0.37		 -2.30%
p = 0.78		 7.93%
p = 0.52
AIR (SUM/FREQ) 2.76
(0.84)		 2.51
(1.05)		 2.36
(0.81)		 9.06%
p = 0.14		 5.98%
p = 0.78		 14.49%
p = 0.11
GSDS            
Sleep quality 4.33
(1.30)		 4.17
(1.24)		 3.51
(0.96)		 3.70%
p = 0.78		 15.83%*
p = 0.21		 18.94%*
p = 0.17
Daytime function 4.00
(1.63)		 4.00
(1.63)		 3.55
(1.30)		 0.00%
p = 1.00		 11.25%*
p = 0.63		 11.25*
p = 0.63
Sleep medication 1.02
(0.87)		 1.06
(0.87)		 1.06
(0.99)		 -3.92%
p = 0.58		 0.00%
p = 0.93		 -3.92%
p = 1.00
Total 3.39
(0.79)		 3.22
(0.82)		 2.80
(0.43)		 5.01%
p = 0.31		 13.04%*
p = 0.12		 17.40%*
p = 0.04**
PANAS^            
Negative affect 23.11
(7.94)		 18.00
(3.91)		 19.56
(7.28)		 22.11%
p = 0.11		 -8.67%
p = 0.37		 15.36%
p = 0.10
Positive affect 21.00
(4.74)		 21.56
(6.11)		 23.33
(6.02)		 -2.67%
p = 0.57		 -8.21%
p = 0.33		 -11.10%
p = 0.18
SF36v2            
Physical component score 33.00
(5.61)		 34.78
(4.63)		 35.33
(2.78)		 -5.39%
p = 0.53		 -1.58%
p = 0.79		 -7.06%
p = 0.34
Mental component score 37.33
(7.84)		 41.56
(6.69)		 41.78
(7.61)		 -11.33%
p = 0.27		 -0.53%
p = 0.94		 -11.92%
p = 0.18
PSQI Total 13.56
(2.92)		 11.00
(2.50)		 9.89
(1.90)		 18.88%*
p = 0.03**		 10.09%*
p = 0.20		 27.06%*
p = 0.02**
*Meets study criteria for Minimal Clinically Important Difference (MCID)
^No published consensus criterion for MCID
**Meets p ≤ 0.05
Table 3: Fibromyalgia Symptom Means and Standard Deviations, Percent Differences in Means, and Significance of Mean Differences from Baseline to Week 8.