Figure 1b: Gender dimorphic genes in the dog associated with adverse event risk and thus the potential for gender risk-associated drug toxicity (left) and those associated with DMPK activity (right). Genes above the line (at ratio 1.0) represent significantly over-expressed genes in male dogs versus female dogs; genes below represent genes significantly under-expressed in male versus female dogs. DMPK Drug Metabolism and Pharmacokinetics; AE Adverse Event.