Figure 1c: Hypothethical interaction of EIF2S3 with GH hormone axis in the dog. Male (‘erratic’) and female (‘continuous’)-specific GH profiles influence the binding of transcriptional factors (potentially STAT5 as established for rodents8), leading to transcription of the post-transcriptional initiation factor EIF2S3 – which, with GTP and initiator tRNA forms a tertiary binding complex to a 40S ribosomal subunit. The high levels of EIF2S3 in the male influence a variety of gender dimorphic effects at the post-transcriptional level. The complicated nature of the interaction may include a direct influence of hormones and phosphorylation.