Test C (Units) 0 hour   2 hours   4 hours   8 hours   24 hours     P-values Signi-ficance Normal
4placebo + 4 Cyclo-Z Mean SEM Mean SEM Mean SEM Mean SEM Mean SEM     Range
Sodium (mmol/L) 139.78 0.3964 139.6 0.4737 138.67 0.4019 140.22 0.8012 139.67 0.4496 0.3402 N.S. 136-146
Potassium (mmol/L) 4.603 0.0778 4.525 0.0877 4.3589 0.0746 4.2778 0.067 4.5133 0.13 0.0875 N.S. 3.5-5.3
Chloride (mmol/L) 90.62 9.138 104.7 0.5126 105.3 0.4942 104.3 0.1306 106 0.4263 0.0537 N.S. 98-106
CO2 (mmol/L) 30.767 0.9025 30.6 0.3464 29.475 0.2496 29.133 0.7535 30.667 0.7965 0.0439 N.S 22-31
Urea Nitrogen (mg/dL) 10.25 0.5789 12* 0.4924 9.5 0.3371 11.0 0.3051 10 0.3051 0.01 * 4.0-15.0
Creatinine (mg/dL) 1.05 0.05436 2.04 0.4743 1.025 0.04462 1.142 0.0617 1.05 0.0544 0.98 N.S. 0.5-1.4
EGFR (mL/min) 94.25 3.745 90.5 7.441 96.25 6.0 86 8.768 91.25 7.779 0.8694 N.S. 100-125
Glucose (mg/dL) 92.5 6.865 90 4.303 85.5 1.252 79.5** 4.398 102.5 5.77 0.005 ** 70-110
Alkaline Phosp. (U/L) 80.25 2.7 76.75 3.757 85.25 1.947 89 2.567 81.5 3.672 0.0577 N.S. 33-94
ALT/WLA (U/L) 21.5 1.098 22.25 0.9383 24.2 2.255 23.5 0.1508 22.75 0.9624 0.4333 N.S. 7.0-45
Bilirubin (mg/dL) 0.7 0.04251 0.675 0.03286 0.65 0.05427 0.525** 0.0329 0.7 0.0564 0.0015 ** 0.2-1
RBC (M/uL) 4.765 0.03045 4.663 0.05759 4.74 0.05518 4.6525 0.0309 4.685 0.0519 0.2831 N.S. 4.4-5.9
Hemoglobin (g/dL) 13.93 0.1453 20.825 3.64 13.8 0.1871 13.78 0.1924 14.275 0.167 0.0637 N.S. 13.3-17.7
Hematocrit (%) 41.075 0.5118 41.325 0.5626 40.9 0.4995 40.975 0.3951 40.85 0.1983 0.8891 N.S. 39-52
MCV (fL) 75.58 6.353 88.525 0.2358 86.25 0.8264 88 0.3844 88.45 0.2841 0.0566 N.S 80-99
MCH (pg) 29.225 0.223 30 0.2093 29.075 0.2847 29.625 0.223 30.4 0.2286 0.0675 N.S. 27-34
MCHC (g/dL) 33.95 0.1098 33.85 0.1177 33.725 0.05789 33.675 0.1875 34.35 0.1515 0.0758 N.S. 32-36
RDW (%) 13.725 0.2093 13.925 0.1436 13.525 0.1303 13.825 0.1911 13.775 0.1009 0.4953 N.S. 12.0-15.0
PLT (k/uL) 294.25 19.803 294.5 20.464 297 20.285 311.5 21.47 295.25 20.556 0.9715 N.S. 150-440
WBC (k/uL) 5.325 0.4294 5.025 0.3582 5.9 0.4848 5.875 0.5077 5.325 0.5475 0.6201 N.S. 4.5-11
LYMP%-A (%) 29.85 1.948 33.475 1.382 34.2 1.357 39.3 1.398 23.2*** 1.452 0.0001 *** 20-40
LYMP#-A (#/uL) 1525 75.001 1625 32.856 1950 96.532 2225 113.57 1175*** 71.904 0.0001 *** 600-4800
Monocyte % (%) 7.9 0.3663 8.43 0.531 8.725 0.5569 7.8 0.5204 6.425* 0.5626 0.0234 * 2.0-10.
Monocyte # (#/uL) 425 39.166 326.38 64.659 525 71.904 475 57.889 325 44.594 0.0801 N.S. 0-950
PMN% (%) 55.725 2.218 54.45 1.728 50.5 1.933 47.775 1.864 67.1*** 1.93 0.0001 *** 41-85
PMN# (#/uL) 2900 285.24 2800 278,8 3025 324.31 2900 347.07 3650 479.83 0.4211 N.S. 1100-7700
Eosinophil % (%) 5.775 7.466 3.9 7.202 6.125 9.893 4.5 8.168 2.9 6.013 0.7778 N.S. 1.0-6.0
Eosinophil # (#/ul) 325 49.43 200 21.32 350 50 250 26.112 150*** 15.076 0.0009 *** 0-500
Basophil % (%) 0.75 0.1485 0.6 0.0522 0.45 0.0151 0.625 0.0653 0.375* 0.0579 0.0159 * 0-1
Basophil # (#/ul) 25 13.056 0 0 0 0 25 13.056 0 0 0.999 N.S. 0-200
*P<0.05; **P<0.01; ***P<0.001 (At 0 vs. At 4 or 8 hours)
Table 3: Study Subjects who took 4 capsules of Cyclo-Z and 4 capsules of Placebos.