Figure 2a-d: light micrographs of sections of liver of fluconazole-treated toads (Haematoxylin and Eosin stain): a- showing multiple intra and extracellular bile thrombi (B). The liver cells show feathery cytoplasm. (Degenerative changes), (X 200). b- Showing marked fatty changes (degenerative changes) with prominent central vein and preserved architecture. (X 200). c- Showing markedly dilated congested blood vessels (Bv) congested sinusoids (S) and multiple bile thrombi (B). (X 200). d- Showing proliferation of bile duct (Bd). (X 100).