Figure 5: Gemcitabine cytotoxicity studies in H1437 cells after siRNA knockdown with negative control siRNAs or with specific siRNAs for ABCC3, ABCC5 or ABCC10. siRNA knockdown of ABCC3, ABCC5 or ABCC10 did not significantly increase gemcitabine cytotoxicity although a combined knockdown of all three did show a statistical significance (p=0.029); knockdown efficiency for each assay is presented; statistically significant values are presented (n=4).