CSM

CYP1 (1A1)

CYP2 (2B4)

CYP3 (3A4)

7

166EAEVLISTLQ175(2.0)a

172CAPCNVIC178(2.4)

187FGVNIDS195(2.0)

8

183HFNPYRY189(1.8)

186RFDYKD191(2.0)

212RFDFLD217(2.0)

9

Absent

217FELFSGF223(1.4)

Absent

10

224FGEVVGSG231(1.4)

226HFPGTHRQI234(1.8)

224IVFPFLI230(1.8)

11

251FKDLNEKFYSF261(1.4)

260PRDFIDVY267(2.4)

258ESRLEDT265(2.0)

The number of CYP sequences analyzed for each family is shown in parenthesis
The CYP sequences used from various species are presented earlier (22)
The colors of the residues in the motifs represent the rank order of sequence
conservation as a function of relative entropy; red is the least conserved (<75%),
black is intermediate (75-90%), and blue represents the most conserved (>90%)
aThe rank is shown in parenthesis
“Absent” in CYP1 and CYP2 represents lack of CSM 9 based on PCPMer motifs
analysis.
Residues and their numbers in the motifs for each CYP family are based on the
specific CYP indicated in the first row
Table 2: Identification and analysis of PCPMer motifs in CYP1 (19), CYP2 (175), and CYP3 (26) families in the E-H regions.